This paper was published by Professor Lian Xiaomei of the Northeast Asian Research Center in the 5th issue of Northeast Asia Forum in 2017 and reprinted in the 2nd issue of Chinese Social Science Digest in 2018. It is divided into four parts, namely the main manifestations of the wave of de-globalization, the influence of de-globalization on regional integration, the prospect of regional cooperation in East Asia, and China's countermeasures to promote regional cooperation in East Asia under the new situation. This article argues that the de-globalization is on the rise, the most prominent manifestation are the objection to government's external transfer of economic sovereignty, the spreading of trade protectionism, and the strong rejection to immigrants and refugees. De-globalization reversed the rapid development trend of regional integration in the previous stage, and might bring regional integration into a low ebb. In this context, the regional cooperation in East Asia might stagnate. As the largest economy as well as the largest overseas market for other East Asian countries, China should play a leading role in East Asia cooperation and explore actively new ways to promote the cooperation.